Swine vesicular disease is a contagious disease of pigs, caused by an enterovirus (Swine vesicular disease virus, SVDV) and characterised by vesicles on the coronary bands, heels of the feet and occasionally on the lips, tongue, snout and teats. Swine vesicular disease can be a subclinical, mild or severe vesicular condition depending on the strain of virus involved, the route and dose of infection, and the husbandry conditions under which the pigs are kept. Its main significance is the strong resemblance to other vesicular diseases, particularly foot and mouth disease. Rapid differentiation of these diseases is critical, as the introduction of foot and mouth disease could cause severe economic losses in non-endemic regions. In addition, the stability of swine vesicular disease virus in the environment complicates its eradication and makes prompt recognition essential for control.