Infection with N. gonorrhoeae is a major cause of pelvic inflammatory disease, ectopic pregnancy, and infertility, and can facilitate HIV transmission. Symptoms of Gonorrhea in men and women vary depending on what part of the body is infected: the anus, eyes, mouth, genitals, or throat. Gonococcal arthritis can also occur, manifestations are a bacteremic infection (arthritis-dermatitis syndrome) or as a localized septic arthritis. Ocular infections by N. gonorrhoeae can have serious consequences of corneal scarring or perforation and occur commonly in newborns who are exposed to infected secretions in the birth canal. Severe cases of Gonorrhea can lead to disseminated infections, endocarditis, and meningitis.