Leptospirosis is a disease that is caused by pathogenic spirochetes of the genus Leptospira. Leptospirosis is considered one of the most common zoonotic diseases globally. Human infections are acquired by direct contact with infected urine or tissue, or indirectly by contact with contaminated water or soil. Most infected persons have a mild to moderate illness. Symptoms include fever, headache, chills, nausea and vomiting, eye inflammation, and muscle aches. In more severe cases, the illness can result in liver damage and jaundice (yellowing of the skin and whites of the eyes), kidney failure, and internal bleeding.