Coronaviruses (CoVs) infect a wide variety of animals and are common throughout the world. They cause respiratory, enteric, hepatic, and neurological diseases with variable severity, from asymptomatic to severe. Coronaviruses that infect mammals (except pigs) belong mainly to two genetic and serologic groups: The Alpha- and Betacoronavirus genera. Coronaviruses are enveloped, positive-sense, single-stranded RNA viruses. Particularly, Human Coronavirus beta have two know types: OC43 (beta coronavirus) and HKU1 (beta coronavirus).