Coronaviruses (CoVs) infect a wide variety of animals and are common throughout the world. They cause respiratory, enteric, hepatic, and neurological diseases with variable severity, from asymptomatic to severe. Coronaviruses that infect mammals (except pigs) belong mainly to two genetic and serologic groups: The Alpha- and Betacoronavirus genera. Coronaviruses are enveloped, positive-sense, single-stranded RNA viruses. Particularly, Human Coronavirus alpha have two know types: 229E (alpha coronavirus) and NL63 (alpha coronavirus).