Human enterovirus 71 (EV71) is an important pathogen caused large outbreaks in Asian-Pacific region with severe neurological complications and may lead to death in young children. Human enterovirus 71 (EV71) is a group of genetically diverse viruses belonging to the genus Enterovirus species A, family Picornaviridae. Infection by EV71 is often asymptomatic, but may manifest as self-limiting disease with mild flu-like symptoms. However, in some cases, EV71 infection may cause polio-like myelitis, brainstem encephalitis, aseptic meningitis, and even death resulting from complications. Enterovirus 71 (EV-71) is notable as one of the major causative agents for hand, foot and mouth diseas.