Chrysanthemum chlorotic mottle viroid (CCMV) is one of two viroids which infect chrysanthemum (Dendranthema grandiflorum). These viroids are the smallest known agents causing infectious disease. The pathogens are small (246-401 nucleotides), circular, single-stranded RNAs. The symptom seen in plants is mild mottle on young leaves then this became in severe yellowing and complete chlorosis on new leaves. The international market for cut and potted chrysanthemums is increasing, and chrysanthemums in many European and Asian countries are commercially very important for the floral industry. CCMV infections of chrysanthemum are a severe problem and its cause losses to the chrysanthemum industry throughout the world.