Brucella canis is the causative agent of canine brucellosis. Transmission to human requires close contact with infected animals or bacterial cultures. The clinical manifestations reported for human, wild-type B. canis infections are fever, headache, anorexia, asthenia, and adenitis. Serious manifestations due to B. canis have been described. These include septic arthritis, aortic valve vegetations, calvarial osteomyelitis, epidural abscess, pleural effusion, oral lesions, and lower extremity aneurysms.