Anaplasma centrale is a Gram-negative bacterium of the Rickettsiales order lacking a traditional cell wall. Infection causes a mild form of anaplasmosis in cattle and has been used as a vaccine against A. marginale. It occurs primarily in warm tropical and subtropical areas. A. centrale is most commonly transmitted by ticks such as Boophilus spp. and Dermacentor spp. Cattle infection presents with fever, loss of appetite, jaundice, anemia and respiratory problems.